VARP Antibody
| Code | Size | Price |
|---|
| PSI-6673-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6673-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
VARP Antibody: VARP, PP12899, Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein
Application Note:
VARP antibody can be used for detection of EPAC1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
VARP Antibody: The VPS9 ankyrin repeat protein (VARP) binds to the Rab21, a guanine nucleotide exchange factor that plays an essential role in endocytic trafficking. VARP localizes to early endosomes and is thought to regulate endosome dynamics. VARP also interacts with TI-VAMP/VAMP7, a vesicular SNARE that mediates an exocytic pathway that is crucial to neurite growth. Depletion of VARP by RNA interference impairs neurite growth, suggesting that VARP is a positive regulator of neurite growth.
Background References:
- Zhang X, He X, Fu XY, et al. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. J. Cell Sci. 2006; 119:1053-62.
- Burgo A, Sotirakis E, Simmler MC, et al. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner in neurite growth. EMBO Rep. 2009; 10:1117-24.
- Alberts P, et al. Cross talk between tetanus neurotoxin-insensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesion. Mol. Biol. Cell 2003; 14:4207-20
Buffer:
VARP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (75%)
Immunogen:
VARP antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human VARP.
The immunogen is located within amino acids 50 - 100 of VARP.
The immunogen is located within amino acids 50 - 100 of VARP.
NCBI Gene ID #:
84079
NCBI Official Name:
ankyrin repeat domain 27 (VPS9 domain)
NCBI Official Symbol:
ANKRD27
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_115515
Protein GI Number:
116063534
Purification:
VARP Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q96NW4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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