RUSC2 Antibody
| Code | Size | Price |
|---|
| PSI-5413-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5413-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Documents
Further Information
Additional Names:
RUSC2 Antibody: Iporin, KIAA0375, Iporin, Interacting protein of Rab1
Application Note:
RUSC2 antibody can be used for detection of RUSC2 by immunohistrochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
RUSC2 Antibody: RUSC2, also known as Iporin, shares with the related protein RUSC1 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC2 is a rab1-interacting protein that also interacts with GM130, another rab1-interacting protein. RUSC2 interacts with specific rab1 isoforms with different rab-binding specificity. It has been suggested that RUSC2 may function as a link between the targeting of ER derived vesicles triggered by the rab1 GTPase and a signaling pathway composed of proteins containing SH3 and/or poly-proline regions.
Background References:
- Bayer M, Fischer J, Kremerskthen J, et al. Identification and characterization of Iporin as a novel interaction partner for rab1. BMC Cell Biol. 2005; 29:6:15.
- Katoh M and Katoh M. Characterization of RUSC1 and RUSC2 genes in silico. Oncol. Rep. 2004; 12:933-8.
- Fukuda M, Kobayashi H, Ishibashi K, et al. Genome-wide investigation of the rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35. Cell Struct. Funct. 2011; 36:155-70
Buffer:
RUSC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (79%)
Immunogen:
RUSC2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RUSC2.
The immunogen is located within amino acids 1410 - 1460 of RUSC2.
The immunogen is located within amino acids 1410 - 1460 of RUSC2.
NCBI Gene ID #:
9853
NCBI Official Name:
RUN and SH3 domain containing 2
NCBI Official Symbol:
RUSC2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001098673
Protein GI Number:
55741719
Purification:
RUSC2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
At least three isoforms are known to exist; this antibody will only detect the longest isoform. This antibody is predicted to not cross-react with RUSC1.
Swissprot #:
Q8N2Y8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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