Periphilin Antibody
| Code | Size | Price |
|---|
| PSI-6687-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6687-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Periphilin Antibody: HSPC206, HSPC232, Periphilin-1, Gastric cancer antigen Ga50
Application Note:
Periphilin antibody can be used for detection of Periphilin by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Periphilin Antibody: Periphilin, known as PPHLN1 or gastric cancer antigen Ga50, plays a role in epithelial differentiation and contributes to epidermal integrity and barrier formation. It interacts with periplakin, a known precursor of the cornified cell envelope. Periphilin 1 is ubiquitously expressed and localizes to nucleus and cytoplasm. Existing as eight alternatively spliced isoforms, Periphilin is highly insoluble and contains a putative nuclear localization signal (NLS) within its N-terminal half, a prerequisite for the formation of insoluble complexes and a possible caspase recognition sequence and a potential nuclear export signal. Periphilin may play an important role in the nervous system.
Background References:
- Kazerounian S and Aho S. Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. J. Biol. Chem. 2003; 278:36707-17.
- Kurita M, Suzuki H, Masai H, et al. Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Biochem. Biophys. Res. Commun. 2004; 324:554-61
- Soehn AS, Pham TT, Schaeferhoff K, et al. Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development. Genesis 2009; 47:697-707
- Soehn AS, Franck T, Biskup S, et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics 2010; 11:203-15
Buffer:
Periphilin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Periphilin antibody was raised against a 16 amino acid synthetic peptide near the center of human Periphilin.
The immunogen is located within amino acids 160 - 210 of Periphilin.
The immunogen is located within amino acids 160 - 210 of Periphilin.
NCBI Gene ID #:
51535
NCBI Official Name:
periphilin 1
NCBI Official Symbol:
PPHLN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_958848
Protein GI Number:
48255929
Purification:
Periphilin Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q8NEY8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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