GBP6 Antibody

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ProSci
Product Code: PSI-6707
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6707-0.02mg0.02mg£150.00
Quantity:
PSI-6707-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of GBP6 in Hela cell lysate with GBP6 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of GBP6 in HeLa cells with GBP6 antibody at 2.5 μg/mL.
3 / 3
Immunofluorescence of GBP6 in HeLa cells with GBP6 antibody at 5 μg/mL.
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Western blot analysis of GBP6 in Hela cell lysate with GBP6 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of GBP6 in HeLa cells with GBP6 antibody at 2.5 μg/mL.
Immunofluorescence of GBP6 in HeLa cells with GBP6 antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
GBP6 Antibody: Guanylate-binding protein 6, GTP-binding protein 6, GBP-6
Application Note:
GBP6 antibody can be used for detection of GBP6 by Western blot at 0.5 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
GBP6 Antibody: The guanylate-binding proteins (GBPs), a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN) (1,3). GBP6 is induced by IFN and hydrolyzes GTP to both GDP and GMP. The precise function of GBP6 is still under investigation.
Background References:
  • Vestal DJ. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.
  • Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.
  • Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.
  • Olszewski MA, Gray J, and Vestal DJ. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Interferon Cytokine Res. 2006; 26:328-52.
Buffer:
GBP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GBP6 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human GBP6.

The immunogen is located within the last 50 amino acids of GBP6.
NCBI Gene ID #:
163351
NCBI Official Name:
guanylate binding protein family, member 6
NCBI Official Symbol:
GBP6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_940862
Protein GI Number:
157671915
Purification:
GBP6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
GBP6 antibody is predicted to not cross-react with other GBP family members.
Swissprot #:
Q6ZN66
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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