NKX2-8 Antibody
| Code | Size | Price |
|---|
| PSI-6753-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6753-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NKX2-8 Antibody: NKX2H, NKX2.8, Nkx2-9, NKX-2.8, NKX2G, NKX2H, Homeobox protein NK-2 homolog H
Application Note:
NKX2-8 antibody can be used for detection of NKX2-8 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NKX2-8 Antibody: NKX2-8 (NK2 homeobox 8) is a member of a family of transcription factors that are involved in embryonic development and cell fate. It is expressed in the ventral foregut, the developing heart, the epithelial layers of the branchial arches and in the dorsal mesoderm. In conjunction with related protein, NKX2-5, NKX2-8 may play a role in cardiac embryonic development. NKX2-8 is also thought to be involved in lung development and is suspected of being an oncogene in lung cancer that is activated by way of gene amplification at chromosome 14q13.
Background References:
- Boettger T, Stein S, and Kessel M. The chicken NKX2.8 homeobox gene: A novel member of the NK-2 gene family. Dev. Genes Evol. 1997; 207:65-70.
- Kendall J, Liu Q, Bakleh A, et al. Oncogenic ccooperation and coamplification of developmental transcription factor genes in lung cancer. Proc. Natl. Acad. Sci. USA 2007; 104:16663-8.
- Hsu DS, Acharya CR, Balakumaran BS, et al. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. Proc. Natl. Acad. Sci. USA 2009; 106:5312-7.
Buffer:
NKX2-8 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NKX2-8 antibody was raised against a 19 amino acid synthetic peptide near the center of human NKX2-8.
The immunogen is located within amino acids 60 - 110 of NKX2-8.
The immunogen is located within amino acids 60 - 110 of NKX2-8.
NCBI Gene ID #:
26257
NCBI Official Name:
NK2 homeobox 8
NCBI Official Symbol:
NKX2-8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055175
Protein GI Number:
31377777
Purification:
NKX2-8 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
NKX2-8 antibody is predicted to not cross-react with other NK2 homeobox family members.
Swissprot #:
O15522
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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