TET2 Antibody
| Code | Size | Price |
|---|
| PSI-6915-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6915-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TET2 Antibody: MDS, KIAA1546, Nbla00191, Methylcytosine dioxygenase TET2
Application Note:
TET2 antibody can be used for detection of TET2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TET2 Antibody: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
Background References:
- Tefferi A, Levine RL, Lim KH, et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIPL1-PDGFRA correlates. Leukemia 2009; 23:900-4.
- Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood 2011; 115:2003-7.
Buffer:
TET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (89%)
Immunogen:
TET2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TET2.
The immunogen is located within amino acids 20 - 70 of TET2.
The immunogen is located within amino acids 20 - 70 of TET2.
NCBI Gene ID #:
54790
NCBI Official Name:
tet methylcytosine dioxygenase 2
NCBI Official Symbol:
TET2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001120680
Protein GI Number:
187761317
Purification:
TET2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
At least two isoforms of TET2 are known to exist; this antibody will detect both isoforms.
Swissprot #:
Q6N021
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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