TSHZ1 Antibody

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ProSci
Product Code: PSI-6755
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6755-0.02mg0.02mg£150.00
Quantity:
PSI-6755-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of TSHZ1 in A-20 cell lysate with TSHZ1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of TSHZ1 in A20 cells with TSHZ1 antibody at 2.5 μg/mL.
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Immunofluorescence of TSHZ1 in A20 cells with TSHZ1 antibody at 20 μg/mL.
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Western blot analysis of TSHZ1 in A-20 cell lysate with TSHZ1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of TSHZ1 in A20 cells with TSHZ1 antibody at 2.5 μg/mL.
Immunofluorescence of TSHZ1 in A20 cells with TSHZ1 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
TSHZ1 Antibody: CAA, TSH1, NY-CO-33, SDCCAG33, Teashirt homolog 1, Antigen NY-CO-33
Application Note:
TSHZ1 antibody can be used for detection of TSHZ1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TSHZ1 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. TSHZ1 has been found to be required for axial skeleton, soft palate and middle ear development in mice and may be involved in a common pathway with the Hox genes. Both TSHZ1 and the related protein TSHZ3 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4.
Background References:
  • Caubit X, Core N, Boned A, et al. Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt. Mech. Dev. 2000; 91:445-8.
  • Santos JS, Fonseca NA, Vieira CP, et al. Phylogeny of the Teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3 in the zebrafish. Dev. Dyn. 2010; 239:1010-8.
  • Core N, Caubit X, Metchat A, et al. Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev. Biol. 2007; 308:407-20
  • Kajiwara Y, Akram A, Katsel P, et al. FE65 binds teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One 2009; 4:e5071.
Buffer:
TSHZ1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TSHZ1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human TSHZ1.

The immunogen is located within amino acids 70 - 120 of TSHZ1.
NCBI Gene ID #:
10194
NCBI Official Name:
teashirt zinc finger homeobox 1
NCBI Official Symbol:
TSHZ1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_005777
Protein GI Number:
38201677
Purification:
TSHZ1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q6ZSZ6
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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