TSHZ2 Antibody

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ProSci
Product Code: PSI-6757
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6757-0.02mg0.02mg£150.00
Quantity:
PSI-6757-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of TSHZ2 in A-20 cell lysate with TSHZ2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunofluorescence of TSHZ2 in A20 cells with TSHZ2 antibody at 20 μg/mL.
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Western blot analysis of TSHZ2 in A-20 cell lysate with TSHZ2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of TSHZ2 in A20 cells with TSHZ2 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
TSHZ2 Antibody: TSH2, ZABC2, ZNF218, OVC10-2, C20orf17, TSH2, Teashirt homolog 2, Ovarian cancer-related protein 10-2
Application Note:
TSHZ2 antibody can be used for detection of TSHZ2 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 5 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TSHZ2 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Recent experiments have shown that the expression of TSHZ2 is frequently downregulated in most breast and prostate cancers and its promoter was unmethylated in virtually all cases, suggesting this family of proteins may also be involved in carcinogenesis.
Background References:
  • Caubit X, Core N, Boned A, et al. Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt. Mech. Dev. 2000; 91:445-8.
  • Santos JS, Fonseca NA, Vieira CP, et al. Phylogeny of the Teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3 in the zebrafish. Dev. Dyn. 2010; 239:1010-8.
  • Caubit X, Tiveron MC, Cremer H, et al. Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. J. Comp. Neurol. 2005; 486:76-88.
  • Yamamoto M, Cid E, Bru S, et al. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers. PLoS ONE 2011; 6:e17149.
Buffer:
TSHZ2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (88%)
Immunogen:
TSHZ2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TSHZ2.

The immunogen is located within amino acids 30 - 80 of TSHZ2.
NCBI Gene ID #:
128553
NCBI Official Name:
teashirt zinc finger homeobox 2
NCBI Official Symbol:
TSHZ2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_775756
Protein GI Number:
153945734
Purification:
TSHZ2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q9NRE2
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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