RNASET2 Antibody
| Code | Size | Price |
|---|
| PSI-6763-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6763-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
RNASET2 Antibody: RNASE6PL, bA514O12.3, RNASE6PL, Ribonuclease T2, Ribonuclease 6
Application Note:
RNASET2 antibody can be used for detection of FOXRED2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
RNASET2 Antibody: RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
Background References:
- Acquati F, Morelli C, Cinquetti R, et al. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene 2001; 20:980-8.
- Campomenosi P, Salis S, Lingqvist C, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochm. Biophys. 2006; 449:17-26
- Polakowski N, Han H, and Lemasson I. Direct inhibition of RNase T2 expression by the HLTV-1 viral protein Tax. Viruses 2011; 3:1485-500.
Buffer:
RNASET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%)
Immunogen:
RNASET2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human RNASET2.
The immunogen is located within the last 50 amino acids of RNASET2.
The immunogen is located within the last 50 amino acids of RNASET2.
NCBI Gene ID #:
8635
NCBI Official Name:
ribonuclease T2
NCBI Official Symbol:
RNASET2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_003721
Protein GI Number:
5231228
Purification:
RNASET2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
O00584
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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