YPEL3 Antibody
| Code | Size | Price |
|---|
| PSI-6775-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6775-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
YPEL3 Antibody: Protein yippee-like 3
Application Note:
YPEL3 antibody can be used for detection of YPEL3 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
YPEL3 Antibody: YPEL3 (yippee-like 3) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL3 is a p53-regulated gene whose expression is induced by DNA damage and in turn induces cellular senescence. It appears to function as a tumor suppressor as it is downregulated in colon and breast tumors.
Background References:
- Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43.
- Kelley K, Miller KR, Todd A, et al. YPEL3, a p53-regulated gene that induces cellular senescence. Cancer Res. 2010; 70:3566-75.
- Tuttle R, Simon R, Hitch DC, et al. Senescence-associated gene YPEL3 is downregulated in human tumors. Ann. Surg. Oncol. 2011; 18:1791-6.
- Tuttle R, Miller KR, Maiorano JN, et al. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. Int. J. Cancer 2011; epub.
Buffer:
YPEL3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
YPEL3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human YPEL3.
The immunogen is located within amino acids 20 - 70 of YPEL3.
The immunogen is located within amino acids 20 - 70 of YPEL3.
NCBI Gene ID #:
83719
NCBI Official Name:
yippee-like 3
NCBI Official Symbol:
YPEL3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_113665
Protein GI Number:
117956405
Purification:
YPEL3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P61236
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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