YPEL4 Antibody
| Code | Size | Price |
|---|
| PSI-6777-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6777-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
YPEL4 Antibody: Protein yippee-like 4
Application Note:
YPEL4 antibody can be used for detection of YPEL4 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
YPEL4 Antibody: YPEL4 (yippee-like 4) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL4 is ubiquitously expressed in adult tissues and has been shown to associate with the major vault protein (MVP). It has been suggested that MVP can inhibit YPEL4's ability to activate Elk-1 in the MAPK signaling pathway.
Background References:
- Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43
- Liang P, Wan Y, Yan Y, et al. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Biochem. Cell. Biol. 2010; 88:445-50.
Buffer:
YPEL4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%)
Immunogen:
YPEL4 antibody was raised against a 12 amino acid synthetic peptide near the amino terminus of human YPEL4.
The immunogen is located within the first 50 amino acids of YPEL4.
The immunogen is located within the first 50 amino acids of YPEL4.
NCBI Gene ID #:
219539
NCBI Official Name:
yippee-like 4
NCBI Official Symbol:
YPEL4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_659445
Protein GI Number:
21450727
Purification:
YPEL4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q96NS1
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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