TMEM106B Antibody
| Code | Size | Price |
|---|
| PSI-6783-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6783-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TMEM106B Antibody: Transmembrane protein 106B
Application Note:
TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TMEM106B Antibody: Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.
Background References:
- Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9.
- Aswathy PM, Jairani PS, and Mathuranath PS. Genetics of frontotemporal lobar degeneration. Ann. Indian Acad. Neurol. 2010; 13(Suppl 2):S55-62.
Buffer:
TMEM106B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (100%), Bovine: (87%), Rat: (86%)
Immunogen:
TMEM106B antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TMEM106B.
The immunogen is located within the first 50 amino acids of TMEM106B.
The immunogen is located within the first 50 amino acids of TMEM106B.
NCBI Gene ID #:
54664
NCBI Official Name:
transmembrane protein 106B
NCBI Official Symbol:
TMEM106B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 30 kDa
Observed: 33 kDa
Observed: 33 kDa
Protein Accession #:
NP_060844
Protein GI Number:
40254893
Purification:
TMEM106B Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.
Swissprot #:
Q9NUM4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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