NCLN Antibody
| Code | Size | Price |
|---|
| PSI-6789-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6789-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NCLN Antibody: NET59, Nicalin, Nicastrin-like protein
Application Note:
NCLN antibody can be used for detection of NCLN by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
Background References:
- Haffner C, Frauli M, Topp S, et al. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. EMBO J. 2004; 23:3041-50.
- Dettmer U, Kuhn PH, Abou-Ajram C, et al. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J. Biol. Chem. 2010; 285:26174-81.
Buffer:
NCLN Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NCLN antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human NCLN.
The immunogen is located within amino acids 390 - 440 of NCLN.
The immunogen is located within amino acids 390 - 440 of NCLN.
NCBI Gene ID #:
56926
NCBI Official Name:
nicalin
NCBI Official Symbol:
NCLN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_064555
Protein GI Number:
51873031
Purification:
NCLN Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q969V3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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