VKORC1 Antibody
| Code | Size | Price |
|---|
| PSI-6795-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6795-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
VKORC1 Antibody: VKOR, MST134, MST576, VKCFD2, EDTP308, IMAGE3455200, VKOR, MSTP134, MSTP576, UNQ308/PRO351, Vitamin K epoxide reductase complex subunit 1, Vitamin K1 2, 3-epoxide reductase subunit 1
Application Note:
VKORC1 antibody can be used for detection of VKORC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
VKORC1 Antibody: Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
Background References:
- Oldenburg J, Bevans CG, Muller CR, et al. Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. Antioxid. Redox Signal. 2006; 8:347-53.
- Rost S, Fregin A, Ivaskevicius V, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 2004; 427:537-41
Buffer:
VKORC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rat: (87%)
Immunogen:
VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1.
The immunogen is located within the first 50 amino acids of VKORC1.
The immunogen is located within the first 50 amino acids of VKORC1.
NCBI Gene ID #:
79001
NCBI Official Name:
vitamin K epoxide reductase complex, subunit 1
NCBI Official Symbol:
VKORC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_076869
Protein GI Number:
13124770
Purification:
VKORC1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q9BQB6
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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