TAB2 Antibody

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ProSci
Product Code: PSI-3389
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3389-0.02mg0.02mg£150.00
Quantity:
PSI-3389-0.1mg0.1mg£449.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)

Images

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Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 μg/mL.
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Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
TAB2 Antibody: CHTD2, MAP3K7IP2, KIAA0733, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2
Application Note:
TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μg/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Background References:
  • Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 2000; 5:649-58.
  • Maizukami J, Takaesu G, Akatsuka H, et al. Receptor activation of NF-kappaB lingand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 2002; 22:992-1000.
  • Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.
Buffer:
TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (86%), Mouse: (79%)
Immunogen:
TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2.

The immunogen is located within the last 50 amino acids of TAB2.
NCBI Gene ID #:
23118
NCBI Official Name:
TGF-beta activated kinase 1/MAP3K7 binding protein 2
NCBI Official Symbol:
TAB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055908
Protein GI Number:
14149669
Purification:
TAB2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Autophagy
SPECIFICITY:
TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
Swissprot #:
Q9NYJ8
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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