TAB3 Antibody
| Code | Size | Price |
|---|
| PSI-3391-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3391-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Documents
Further Information
Additional Names:
TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3
Application Note:
TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Background References:
- Cheung PC, Nebreda AR, and Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004; 378:27-34.
- Besse A, Lamothe B, Campos AD, et al. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J. Biol. Chem. 2007; 282:3918-28.
- Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.
Buffer:
TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (92%)
Immunogen:
TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3.
The immunogen is located within amino acids 40 - 90 of TAB3.
The immunogen is located within amino acids 40 - 90 of TAB3.
NCBI Gene ID #:
257397
NCBI Official Name:
TGF-beta activated kinase 1/MAP3K7 binding protein 3
NCBI Official Symbol:
TAB3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_690000
Protein GI Number:
98991767
Purification:
TAB3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Autophagy
SPECIFICITY:
TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.
Swissprot #:
Q8N5C8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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