TTBK2 Antibody
| Code | Size | Price |
|---|
| PSI-5021-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5021-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Documents
Further Information
Additional Names:
TTBK2 Antibody: TTBK, SCA11, KIAA0847, Tau-tubulin kinase 2
Application Note:
TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
Background References:
- Kitano-Takahashi M, Morita H, Kondo S, et al. Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007; 63:602-4.
- Edener U, Kurth I, Meiner A, et al. Missense exchanges in the TTBK2 gene mutated in SCA11. J. Neurol. 2009; 1856-9.
- Bender C and Ullrich A. PRKX, TTBK2 and RSK4 expression causes sunitinib resistance in kidney carcinoma- and melanoma cell lines. Int. J. Cancer 2011; epub.
Buffer:
TTBK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (88%)
Immunogen:
TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2.
The immunogen is located within the last 50 amino acids of TTBK2.
The immunogen is located within the last 50 amino acids of TTBK2.
NCBI Gene ID #:
146057
NCBI Official Name:
tau tubulin kinase 2
NCBI Official Symbol:
TTBK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAH71556
Protein GI Number:
47940064
Purification:
TTBK2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist; this antibody will detect only the two largest isoforms.
Swissprot #:
Q6IQ55
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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