WDR35 Antibody
| Code | Size | Price |
|---|
| PSI-5867-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5867-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Documents
Further Information
Additional Names:
WDR35 Antibody: CED2, IFTA1, SRTD7, IFT121, KIAA1336, WD repeat-containing protein 35, Intraflagellar transport protein 121 homolog
Application Note:
WDR35 antibody can be used for detection of WDR35 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
WDR35 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.
Background References:
- Gilissen C, Arts HH, Hoischen A, et al. Exome sequencing identifies WDR35 variants involded in Sensenbrenner syndrome. Am. J. Hum. Genet. 2010; 87:418-23.
- Mill P, Lockhart PJ, Fitzpatrick E, et al. Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J. Hum. Genet. 2011; 88:508-15.
Buffer:
WDR35 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%)
Immunogen:
WDR35 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human WDR35.
The immunogen is located within amino acids 60 - 110 of WDR35.
The immunogen is located within amino acids 60 - 110 of WDR35.
NCBI Gene ID #:
57539
NCBI Official Name:
WD repeat domain 35
NCBI Official Symbol:
WDR35
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001006658
Protein GI Number:
55743161
Purification:
WDR35 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
WDR35 antibody is human specific.
Swissprot #:
Q9P2L0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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