TTYH2 Antibody
| Code | Size | Price |
|---|
| PSI-6885-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6885-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TTYH2 Antibody: C17orf29, C17orf29, Protein tweety homolog 2, hTTY2
Application Note:
TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.
Background References:
- Rae FK, Hooper JD, Eyre HJ, et al. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Genomics 2001; 77:200-7.
- Toiyama Y, Mizoguchi A, Kimura K, et al. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. World J. Gastroenterol. 2007; 13:2717-21
- He Y, Hryciw DH, Carroll ML, et al. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. J. Biol. Chem. 2008; 283:24000-10.
Buffer:
TTYH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2.
The immunogen is located within amino acids 60 - 110 of TTYH2.
The immunogen is located within amino acids 60 - 110 of TTYH2.
NCBI Gene ID #:
94015
NCBI Official Name:
tweety homolog 2 (Drosophila)
NCBI Official Symbol:
TTYH2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_116035
Protein GI Number:
53988385
Purification:
TTYH2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
At least four isoforms of TTYH2 are known to exist; this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.
Swissprot #:
Q9BSA4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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