SARM Antibody

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ProSci
Product Code: PSI-6917
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6917-0.02mg0.02mg£150.00
Quantity:
PSI-6917-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of SARM in Daudi cell lysate with SARM antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of SARM in human kidney tissue with SARM antibody at 20 μg/mL.
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Western blot analysis of SARM in Daudi cell lysate with SARM antibody at (A) 1 and (B) 2 μg/mL.
Immunofluorescence of SARM in human kidney tissue with SARM antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
SARM Antibody: SARM, SAMD2, MyD88-5, KIAA0524, SARM, Sterile alpha and TIR motif-containing protein 1, Sterile alpha and Armadillo repeat protein
Application Note:
SARM antibody can be used for detection of SARM by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SARM Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-κB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.
Background References:
  • Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
  • Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
  • Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
  • O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Buffer:
SARM Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (88%)
Immunogen:
SARM antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SARM.

The immunogen is located within amino acids 30 - 80 of SARM.
NCBI Gene ID #:
23098
NCBI Official Name:
sterile alpha and TIR motif containing 1
NCBI Official Symbol:
SARM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055892
Protein GI Number:
154090976
Purification:
SARM Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. SARM antibody recognize the longest isoform.
Swissprot #:
Q6SZW1
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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