DELE Antibody
| Code | Size | Price |
|---|
| PSI-6919-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6919-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
DELE Antibody: DELE, DELE, Death ligand signal enhancer
Application Note:
DELE antibody can be used for detection of DELE by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
Background References:
- Harada T, Iwai A, Miyazaki T. Identification of DELE, a novel DAP-binding protein which is crucial for death receptor-mediated apoptosis induction. Apoptosis 2010; 15:1247-55.
Buffer:
DELE Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (71%)
Immunogen:
DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.
The immunogen is located within the first 50 amino acids of DELE.
The immunogen is located within the first 50 amino acids of DELE.
NCBI Gene ID #:
9812
NCBI Official Name:
KIAA0141
NCBI Official Symbol:
KIAA0141
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055588
Protein GI Number:
217330656
Purification:
DELE Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q14154
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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