CASK Antibody

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ProSci
Product Code: PSI-6921
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6921-0.02mg0.02mg£150.00
Quantity:
PSI-6921-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of CASK in mouse brain tissue lysate with CASK antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
2 / 2
Immunofluorescence of CASK in human brain tissue with CASK antibody at 20 μg/mL.
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Western blot analysis of CASK in mouse brain tissue lysate with CASK antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of CASK in human brain tissue with CASK antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
CASK Antibody: CMG, FGS4, LIN2, TNRC8, CAGH39, CAMGUK, MICPCH, MRXSNA, Peripheral plasma membrane protein CASK, Protein lin-2 homolog, hCASK
Application Note:
CASK antibody can be used for detection of CASK by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CASK Antibody: CASK (Calcium/calmodulin-dependent serine protein kinase), a conserved multi-domain scaffolding protein, belongs to a MAGUK (membrane-associated guanylate kinase homologs) subfamily and is involved in cell junction organization, tumor suppression and signaling. It is characterized by a novel domain structure that consists of a calcium/calmodulin-dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is ubiquitously expressed and significantly greater in brain where it is thought to be involved in signaling at neuronal synapses. CASK interacts with CASKINs and defects in CASK are the cause of mental retardation X-linked CASK-related.
Background References:
  • Dimitratos SD, Woods DF, and Bryant PJ. Camguk, Lin-2, and CASK: novel membrane associated guanylate kinase homologs that also contain CaM kinase domains. Mech. Dev. 1997; 63:127-30.
  • Hsueh YP and Sheng M. Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J. Neurosci. 1999;19:7415-25.
  • Tabuchi K, Biederer T, Butz S, et al. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with CASKIN2, a novel CASK-binding protein. J. Neurosci. 2002; 22:4264-73.
  • Kuo TY, Hong CJ, Chien HL, et al. X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J. Neurosci. Res. 2010; 88: 2364-73.
Buffer:
CASK Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CASK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CASK.

The immunogen is located within amino acids 760 - 810 of CASK.
NCBI Gene ID #:
8573
NCBI Official Name:
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
NCBI Official Symbol:
CASK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_003679
Protein GI Number:
186972120
Purification:
CASK Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least six alternatively spliced transcript variants have been observed.
Swissprot #:
O14936
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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