COH1 Antibody
| Code | Size | Price |
|---|
| PSI-6931-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6931-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
COH1 Antibody: CHS1, COH1, CHS1, KIAA0532, Vacuolar protein sorting-associated protein 13B, Cohen syndrome protein 1
Application Note:
COH1 antibody can be used for detection of COH1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
COH1 Antibody: COH1 (Cohen syndrome protein 1), also known as VPS13B (vacuolar protein sorting-associated protein 13B) or CHS1, belongs to the VPS13 family and may function in vesicle-mediated transport and sorting of proteins within the cell. COH1 is widely expressed and multiple alternatively spliced transcript variants have been observed. Mutations in this gene have been associated with Cohen syndrome. COH1 is a Golgi-localized peripheral membrane protein and plays a critical role in Golgi (re)assembly.
Background References:
- Velayos-Baeza A, Vettori A, Copley RR, et al. Analysis of the human VPS13 gene family. Genomics 2004; 84:536-49.
- Kolehmainen J, Black GC, Saarinen A, et al. Cohen syndrome is caused by mutations in a novel gene, COH1, encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport. Am. J. Hum. Genet. 2003; 72:1359-69.
- Seifert W, K?hnisch J, Maritzen T, et al. Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity. J. Biol. Chem. 2011; 286:37665-75.
Buffer:
COH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
COH1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human COH1.
The immunogen is located within amino acids 90 - 140 of COH1.
The immunogen is located within amino acids 90 - 140 of COH1.
NCBI Gene ID #:
157680
NCBI Official Name:
vacuolar protein sorting 13 homolog B (yeast)
NCBI Official Symbol:
VPS13B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_056058
Protein GI Number:
35493725
Purification:
COH1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least five alternatively spliced transcript variants have been observed. COH1 detects two isoforms.
Swissprot #:
Q7Z7G8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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