CCDC22 Antibody
| Code | Size | Price |
|---|
| PSI-6933-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6933-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CCDC22 Antibody: JM1, CXorf37, JM1, Coiled-coil domain-containing protein 22
Application Note:
CCDC22 antibody can be used for detection of CCDC22 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CCDC22 Antibody: CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID).
Background References:
- Tomsig JL, Snyder SL, and Creutz CE. Identification of targets for calcium signaling through the copine family of proteins. J. Biol. Chem. 2003; 278:10048-54.
- Mulder J, Bjorling E, Jonasson K, et al. Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. Mol. Cell Prot. 2009; 8:1612-22.
- Mulder J, Wernerus H, Shi TJ, et al. Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system. Neurosci.2007; 146:1689-703
- Voineagu I, Huang L, Winden K, et al. CCDC22: a novel candidate gene for syndromic X-linked intellectual disability. Mol. Psych. 2012; 17:4-7.
Buffer:
CCDC22 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
CCDC22 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC22.
The immunogen is located within amino acids 530 - 580 of CCDC22.
The immunogen is located within amino acids 530 - 580 of CCDC22.
NCBI Gene ID #:
28952
NCBI Official Name:
coiled-coil domain containing 22
NCBI Official Symbol:
CCDC22
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_054727
Protein GI Number:
7661844
Purification:
CCDC22 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least three isoforms of CCDC22 are known to exist; this antibody will detect the two largest isoforms.
Swissprot #:
O60826
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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