CLEC2A Antibody
| Code | Size | Price |
|---|
| PSI-6959-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6959-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CLEC2A Antibody: KACL, PILAR, UNQ5792, KACL, UNQ5792/PRO19597, C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin
Application Note:
CLEC2A antibody can be used for detection of CLEC2A by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8(+), B lymphocytes and naive CD4(+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.
Background References:
- Huarte E, Cubillos-Ruiz JR, Nesbeth YC, et al. PILAR is a novel modulator of human T-cell expansion. Blood 2008; 112:1259-68.
- Drickamer K. C-type lectin-like domains. Curr. Opin. Struct. Biol. 1999; 9:585-90
- Spreu J, Kienle EC, Schrage B, et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 2007; 59:903-12.
- Spreu J, Kuttruff S, Stejfova V, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. USA 2010; 107:5100-5.
Buffer:
CLEC2A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CLEC2A antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CLEC2A.
The immunogen is located within the first 50 amino acids of CLEC2A.
The immunogen is located within the first 50 amino acids of CLEC2A.
NCBI Gene ID #:
387836
NCBI Official Name:
C-type lectin domain family 2, member A
NCBI Official Symbol:
CLEC2A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001124183
Protein GI Number:
195222725
Purification:
CLEC2A Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.
Swissprot #:
Q6UVW9
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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