CRIM1 Antibody

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ProSci
Product Code: PSI-6961
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6961-0.02mg0.02mg£150.00
Quantity:
PSI-6961-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of CRIM1 in Jurkat cell lysate with Crim1 antibody at 1 μg/mL.
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Immunofluorescence of CRIM1 in Jurkat cells with CRIM1 antibody at 20 μg/mL.
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Western blot analysis of CRIM1 in Jurkat cell lysate with Crim1 antibody at 1 μg/mL.
Immunofluorescence of CRIM1 in Jurkat cells with CRIM1 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
CRIM1 Antibody: S52, CRIM-1, S52, UNQ1886/PRO4330, Cysteine-rich motor neuron 1 protein, Cysteine-rich repeat-containing protein S52
Application Note:
CRIM1 antibody can be used for detection of Crim1 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CRIM1 Antibody: CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
Background References:
  • Kolle G, Georgas K, Holmes GP, et al. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech. Dev. 2000; 90:181-93.
  • Glienke J, Sturz A, Menrad A, et al. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. Mech. Dev. 2002; 119:165-75.
  • Wilkinson L, Kolle G, Wen D, et al. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. J. Biol. Chem. 2003; 278:34181-8.
  • Pennisi DJ, Kinna G, Chiu HS, et al. Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta. Placenta 2012; 33:175-82.
Buffer:
CRIM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (88%)
Immunogen:
CRIM1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Crim1.

The immunogen is located within amino acids 910 - 960 of CRIM1.
NCBI Gene ID #:
51232
NCBI Official Name:
cysteine rich transmembrane BMP regulator 1 (chordin-like)
NCBI Official Symbol:
CRIM1
NCBI Organism:
homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_057525
Protein GI Number:
10092639
Purification:
CRIM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.
Swissprot #:
Q9NZV1
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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