EMX2 Antibody
| Code | Size | Price |
|---|
| PSI-4099-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4099-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Documents
Further Information
Additional Names:
EMX2 Antibody: Homeobox protein EMX2, Empty spiracles homolog 2
Application Note:
EMX2 antibody can be used for detection of EMX2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
EMX2 Antibody: EMX2, like its closely related homolog EMX1, is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and participates in the development of olfactory neurons. EMX2 is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10.
Background References:
- Bishop KM, Garel S, Nakagawa Y, et al. EMX1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J. Comp. Neurol. 2003; 457:345-60.
- Lichtneckert R, Nobs L, Reichert H. Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila. Development 2008; 135:2415-24.
- Gulisano M, et al. EMX2 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse. Eur. J. Neurosci. 1996; 8:1037-50.
- Nedelec S, Foucher I, Brunet I, et al. Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc. Natl. Acad. Sci. USA 2004; 101:10815-20.
Buffer:
EMX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (94%), Bovine: (94%)
Immunogen:
EMX2 antibody was raised against an 16 amino acid synthetic peptide near the amino terminus of human EMX2.
The immunogen is located within the first 50 amino acids of EMX2.
The immunogen is located within the first 50 amino acids of EMX2.
NCBI Gene ID #:
2018
NCBI Official Name:
empty spiracles homeobox 2
NCBI Official Symbol:
EMX2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
Q04743
Protein GI Number:
19862512
Purification:
EMX2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
At least two isoforms of EMX2 are known to exist; this antibody will detect both isoforms. EMX2 antibody is predicted to not cross-react with EMX1.
Swissprot #:
Q04743
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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