CASKIN1 Antibody
| Code | Size | Price |
|---|
| PSI-6991-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6991-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CASKIN1 Antibody: ANKS5A, KIAA1306, Caskin-1, CASK-interacting protein 1
Application Note:
CASKIN1 antibody can be used for detection of CASKIN1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
CASKIN1 Antibody: Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain scaffolding protein involved in brain development, synapse formation, and establishment of cell polarity. CASKINs (CASK interacting proteins) interact with CASK and is thought to play a role in CASK function, specifically by coupling CASK to distinct downstream effectors. CASKIN1 is a multidomain protein containing six N-terminal ankyrin repeats, one SH3 domain, and two sterile alpha motif domains followed by a long proline-rich sequence and a short conserved C-terminal domain. CASKIN1 coassembles with CASK on the cytoplasmic tail of neurexin 1, suggesting that CASKIN and CASK coat the cytoplasmic tails of neurexins and other cell-surface proteins.
Background References:
- Stafford RL, Ear J, Knight MJ, et al. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J. Mol. Biol. 2011; 412:3-13.
- Weng YL, Liu N, DiAntonio A, et al. The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. Neurosci. 2011; 31:4421-33.
- Tabuchi K, Biederer T, Butz S, et al. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with CASKIN1, a novel CASK-binding protein. J. Neurosci. 2002; 22:4264-73.
Buffer:
CASKIN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (71%), Rat: (71%)
Immunogen:
CASKIN1 antibody was raised against a 17 amino acid synthetic peptide near the center of human CASKIN1.
The immunogen is located within amino acids 720 - 770 of CASKIN1.
The immunogen is located within amino acids 720 - 770 of CASKIN1.
NCBI Gene ID #:
57524
NCBI Official Name:
CASK interacting protein 1
NCBI Official Symbol:
CASKIN1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 157 kDa
Observed: 160 kDa
Observed: 160 kDa
Protein Accession #:
NP_065815
Protein GI Number:
18079216
Purification:
CASKIN1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
CASKIN1 antibody is predicted to not cross-react with other CASKIN family members.
Swissprot #:
Q8WXD9
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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