CDKN1C Antibody
| Code | Size | Price |
|---|
| PSI-7015-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7015-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CDKN1C Antibody: BWS, WBS, p57, BWCR, KIP2, p57Kip2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57
Application Note:
CDKN1C antibody can be used for detection of CDKN1C by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CDKN1C Antibody: The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.
Background References:
- Lee MH, Reynisdottir I, and Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995; 9:639-49.
- Pateras IS, Apostolopoulou K, Niforou K, et al. p57KIP2: ?Kip"ing the cell under control. Mol. Cancer Res. 2009; 1902-19
- Hatada I, Ohashi H, Fukushima Y, et al. An imprinted p57KIP2 is mutated in Beckwith-Wiedemann syndrome. Nat. Genet. 1996; 14:171-3.
Buffer:
CDKN1C Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (88%)
Immunogen:
CDKN1C antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CDKN1C.
The immunogen is located within amino acids 40 - 90 of CDKN1C.
The immunogen is located within amino acids 40 - 90 of CDKN1C.
NCBI Gene ID #:
1028
NCBI Official Name:
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Official Symbol:
CDKN1C
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
35 kDa
Protein Accession #:
NP_000067
Protein GI Number:
4557441
Purification:
CDKN1C Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
At least three isoforms of CDKN1C are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, CDKN1C often migrates at 57kDa in SDS-PAGE. CDKN1C antibody is predicted to not cross react with other CIP/KIP proteins.
Swissprot #:
P49918
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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