DLK1 Antibody
| Code | Size | Price |
|---|
| PSI-7017-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7017-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
DLK1 Antibody: DLK, Protein delta homolog 1, pG2, DLK-1
Application Note:
DLK1 antibody can be used for detection of DLK1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
DLK1 Antibody: The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.
Background References:
- Smas CM and Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993; 73:725-34.
- Sul HS. Mini-review: Pref-1: role in adipogenesis and mesenchymal cell fate. Mol. Endocrinol. 2009; 23:1717-25.
- Kawakami T, Chano T, Minami K, et al. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum. Mol. Genet. 2006; 15:821-30.
- Wermter AK, Scherag A, Meyre D, et al. Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdomainance in human. Eur. J. Hum. Genet. 2008; 16:1126-34.
Buffer:
DLK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DLK1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DLK1.
The immunogen is located within amino acids 260 - 310 of DLK1.
The immunogen is located within amino acids 260 - 310 of DLK1.
NCBI Gene ID #:
8788
NCBI Official Name:
delta-like 1 homolog (Drosophila)
NCBI Official Symbol:
DLK1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
NP_003827
Protein GI Number:
74136023
Purification:
DLK1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
At least four isoforms of DLK1 are known to exist.
Swissprot #:
P80370
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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