EPM2A Antibody
| Code | Size | Price |
|---|
| PSI-7023-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7023-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
EPM2A Antibody: EPM2, MELF, Laforin, Lafora PTPase, LAFPTPase
Application Note:
EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
Background References:
- Minassian BA, Lee JR, Herbrick JA, et al. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat. Genet. 1998; 20:171-4.
- Worby CA, Gentry MS, and Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J. Biol. Chem. 2006; 281:30412-8.
Buffer:
EPM2A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EPM2A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human EPM2A.
The immunogen is located within amino acids 190 - 240 of EPM2A.
The immunogen is located within amino acids 190 - 240 of EPM2A.
NCBI Gene ID #:
7957
NCBI Official Name:
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
NCBI Official Symbol:
EPM2A
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
36 kDa
Protein Accession #:
NP_005661
Protein GI Number:
11321613
Purification:
EPM2A Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least four isoforms of EPM2A are known to exist; this antibody will detect all but the shortest isoform.
Swissprot #:
O95278
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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