TCTEX1D4 Antibody

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ProSci
Product Code: PSI-6957
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6957-0.02mg0.02mg£150.00
Quantity:
PSI-6957-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of TCTEX1D4 in mouse liver tissue lysate with TCTEX1D4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunofluorescence of TCTEX1D4 in human liver tissue with TCTEX1D4 antibody at 20 μg/mL.
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Western blot analysis of TCTEX1D4 in mouse liver tissue lysate with TCTEX1D4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of TCTEX1D4 in human liver tissue with TCTEX1D4 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
TCTEX1D4 Antibody: Tctex1 domain-containing protein 4, Tctex-2-beta
Application Note:
TCTEX1D4 antibody can be used for detection of TCTEX1D4 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TCTEX1D4 Antibody: Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D4, also called TCTEX2 beta, interacts with different members of the TGF-beta receptor family, and when overexpressed, inhibits TGF-beta signaling.
Background References:
  • He Y, Francis F, Myers KA, et al. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. J. Cell Biol. 2005; 168:697-703.
  • Li J, Lee WL, and Cooper JA. NudEL targets dynein to microtubule ends through LIS1. Nat. Cell Biol. 2005; 7:686-90.
  • Watanabe TK, Fujiwara T, Shimizu F, et al. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1 to 6q. Cytogenet. Cell Genet. 1996; 73:153-6.
  • Chuang JZ, Yeh TY, Bollati F, et al. The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev. Cell 2005; 9:75-86.
Buffer:
TCTEX1D4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (74%)
Immunogen:
TCTEX1D4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCTEX1D4.

The immunogen is located within the first 50 amino acids of TCTEX1D4.
NCBI Gene ID #:
343521
NCBI Official Name:
Tctex1 domain containing 4
NCBI Official Symbol:
TCTEX1D4
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
NP_001013654
Protein GI Number:
61966721
Purification:
TCTEX1D4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
TCTEX1D4 is predicted to not cross-react with other members of the TCTEX-type family.
Swissprot #:
Q5JR98
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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