DCP2 Antibody
| Code | Size | Price |
|---|
| PSI-7049-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7049-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
DCP2 Antibody: NUDT20, NUDT20, m7GpppN-mRNA hydrolase, Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20
Application Note:
DCP2 antibody can be used for detection of DCP2 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
DCP2 Antibody: The removal, or decapping, of eukaryotic mRNA is an important step in the degradation of mRNA. Decapping protein 2 (DCP2) is the major mRNA decapping enzyme in cells. It is a member of the Nudix hydrolases superfamily of proteins that predominantly catalyze the hydrolysis of small nucleoside diphosphate substrates linked to another moiety. DCP2 is widely expressed in multiple tissues at varying levels, with highest expression seen in testis and brain.
Background References:
- Song MG, Li Y, and Kiledjian M. Multiple mRNA decapping enzymes in mammalian cells. Mol. Cell 2010; 40:423-32.
- Dunckley T and Parker R. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J. 18:5411-22.
- Bessman MJ, Frick DN, and O'Handley SF. The MutT proteins of ?Nudix" hydrolases, a family of versatile, widely distributed, ?housecleaning" enzymes. J. Biol. Chem. 1996; 271:25059-62
Buffer:
DCP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DCP2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DCP2.
The immunogen is located within amino acids 340 - 390 of DCP2.
The immunogen is located within amino acids 340 - 390 of DCP2.
NCBI Gene ID #:
167227
NCBI Official Name:
DCP2 decapping enzyme homolog (S. cerevisiae)
NCBI Official Symbol:
DCP2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
NP_689837
Protein GI Number:
31542498
Purification:
DCP2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
Multiple isoforms of DCP2 are known to exist.
Swissprot #:
Q8IU60
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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