VNN3 Antibody
| Code | Size | Price |
|---|
| PSI-7057-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7057-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
VNN3 Antibody: HSA238982, Vascular non-inflammatory molecule 3, Vanin-3
Application Note:
VNN3 antibody can be used for detection of VNN3 by Western blot at 0.5 and 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
VNN3 Antibody: The vanin family is a novel group of ectoenzymes that function in tissue repair and plays a role in oxidative-stress response. As both secreted and membrane proteins, the vanin family members have been implicated as therapeutic targets in inflammatory disease. VNN3 (vascular non-inflammatory molecule 3), also known as Vanin3, is a 501 amino acid GPI-anchored amidohydrolase that is widely expressed and is found at highest levels in blood and liver. Induced by Th17 / Th1 type cytokines, VNN3 converts pantetheine into pantothenic acid. Containing one CN hydrolase domain, VNN3 is encoded by a gene that maps to human chromosome 6q23.2.
Background References:
- Granjeaud S, Naquet P and Galland F. An ESTs description of the new Vanin gene family conserved from fly to human. Immunogenetics 1999; 49:964-72.
- Jansen PA, Kamsteeg M, Rodijk-Olthuis D, et al. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. J. Invest. Dermatol. 2009;129:2167-74.
- Nitto T, Inoue T and Node K. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. Gene 2008; 426:57-64.
- Martin F, Malergue F, Pitari G, et al. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics 2001; 53:296-306.
Buffer:
VNN3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
VNN3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human VNN3.
The immunogen is located within the last 50 amino acids of VNN3.
The immunogen is located within the last 50 amino acids of VNN3.
NCBI Gene ID #:
55350
NCBI Official Name:
vanin 3
NCBI Official Symbol:
VNN3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
Q9NY84
Protein GI Number:
88952267
Purification:
VNN3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
Multiple isoforms of VNN3 are known to exist.
Swissprot #:
Q9NY84
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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