CMPK2 Antibody

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ProSci
Product Code: PSI-7063
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-7063-0.02mg0.02mg£150.00
Quantity:
PSI-7063-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of CMPK2 in rat lung tissue lysate with CMPK2 antibody at 1 μg/mL
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Immunofluorescence of CMPK2 in human lung tissue with CMPK2 antibody at 20 μg/mL.
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Western blot analysis of CMPK2 in rat lung tissue lysate with CMPK2 antibody at 1 μg/mL
Immunofluorescence of CMPK2 in human lung tissue with CMPK2 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
CMPK2 Antibody: TYKi, TMPK2, UMP-CMPK2, UMP-CMP kinase 2, mitochondrial, Nucleoside-diphosphate kinase
Application Note:
CMPK2 antibody can be used for detection of CMPK2 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CMPK2 Antibody: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response
Background References:
  • Xu Y, Johansson M, Karlsson A. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. J. Biol. Chem. 2008; 283:1563-71.
  • Chen YL, Lin DW, and Chang ZF. Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation. Genes Cells 2008; 13:679-89.
  • Arima T, Akiyoshi H, and Fujii S. Characterization of pyrimidine nucleoside monophosphokinase in normal and malignant tissues. Cancer Res. 1977; 37:1593-7.
  • Goertsches RH, Hecker M, Koczan D, et al. Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS. Pharmacogenomics 2010;11:147-61.
Buffer:
CMPK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CMPK2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2.

The immunogen is located within amino acids 370 - 420 of CMPK2.
NCBI Gene ID #:
129607
NCBI Official Name:
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
NCBI Official Symbol:
CMPK2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
Protein Accession #:
NP_997198
Protein GI Number:
117606370
Purification:
CMPK2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
Multiple isoforms of CMPK2 are known to exist.
Swissprot #:
Q5EBM0
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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