NGN2 Antibody
| Code | Size | Price |
|---|
| PSI-7091-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7091-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NGN2 Antibody: NGN2, Atoh4, ngn-2, Math4A, bHLHa8, ATOH4, BHLHA8, NGN2, Neurogenin-2, Class A basic helix-loop-helix protein 8, NGN-2
Application Note:
NGN2 antibody can be used for detection of NGN2 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NGN2 Antibody: Neurogenin-2 (NGN2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. NGN2 is thought to work with Nurr1 to play a role in the differentiation and survival of midbrain dopaminergic neurons. It has also been suggested for use in human embryonic neural progenitors as a graft for spinal cord injuries
Background References:
- Sommer L, Ma Q, and Anderson DJ. Neurogenins, a novel family of atonal-related bHLH transcription factors, a putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell Neurosci. 1996; 8:221-41.
- Fode C, Gradwohl G, Morin X, et al. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 1998; 20:483-94.
- Andersson EK, Irvin DK, Ahlsio J, et al. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Exp. Cell. Res. 2007; 313:1172-80.
- Perrin FE, Boniface G, Serguera C, et al. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS One 2010; 5:e15914.
Buffer:
NGN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal NGN2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human NGN2.
The immunogen is located within the last 50 amino acids of NGN2.
The immunogen is located within the last 50 amino acids of NGN2.
NCBI Gene ID #:
63973
NCBI Official Name:
neurogenin 2
NCBI Official Symbol:
NEUROG2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
30 kDa
Protein Accession #:
NP_076924
Protein GI Number:
31077092
Purification:
NGN2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
NGN2 antibody is predicted to not cross-react with neurogenin 1.
Swissprot #:
Q9H2A3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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