PANX1 Antibody
| Code | Size | Price |
|---|
| PSI-7097-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7097-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PANX1 Antibody: PX1, MRS1, UNQ2529, UNQ2529/PRO6028, Pannexin-1
Application Note:
PANX1 antibody can be used for detection of PANX1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PANX1 Antibody: The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
Background References:
- Barbe MT, Monyer H and Bruzzone R. Cell-cell communication beyond connexins: the pannexin channels. Physiology 2006; 21:103-14.
- Baranova A, Ivanov D, Petrash N, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83:706-16.
- Sohl G, Maxeiner S and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 2005; 6:191-200
- Bao L, Locovei S and Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 2004; 572:65-8.
Buffer:
PANX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal PANX1 antibody was raised against a 17 amino acid peptide near the amino terminus of human PANX1.
The immunogen is located within amino acids 70 - 120 of PANX1.
The immunogen is located within amino acids 70 - 120 of PANX1.
NCBI Gene ID #:
24145
NCBI Official Name:
pannexin 1
NCBI Official Symbol:
PANX1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
NP_056183
Protein GI Number:
39995064
Purification:
PANX1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
Two transcript variants encoding different isoforms have been found for this gene.
Swissprot #:
Q96RD7
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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