RTN4RL2 Antibody
| Code | Size | Price |
|---|
| PSI-7145-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7145-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
RTN4RL2 Antibody: NgR2, NGRH1, NGRL3, Reticulon-4 receptor-like 2, Nogo receptor-like 3, NgR2
Application Note:
RTN4RL2 antibody can be used for detection of RTN4RL2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
RTN4RL2 Antibody: Reticulon 4 receptor-like 2 (RTN4RL2), also known as NgR2and NgRH1, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich sequences at both the N- and C-termini. The membrane anchored RTN4RL2 can be solubilized through the action of phospholipase or an unidentified MTMMP to generate a 46 kDa soluble receptor. It has been suggested that RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Background References:
- Pignot V, Hein AE, Barske C, et al. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J. Neurochem. 2003; 85:717-28.
- Venkatesh K, Chivatakam O, Lee H, et al. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J. Neurosci. 2005; 25:808-22.
Buffer:
RTN4RL2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)
Immunogen:
Rabbit polyclonal RTN4RL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RTN4RL2.
The immunogen is located within amino acids 330 - 380 of RTN4RL2.
The immunogen is located within amino acids 330 - 380 of RTN4RL2.
NCBI Gene ID #:
349667
NCBI Official Name:
reticulon 4 receptor-like 2
NCBI Official Symbol:
RTN4RL2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 46 kDa
Protein Accession #:
NP_848665
Protein GI Number:
30425563
Purification:
RTN4RL2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
Three alternatively spliced transcript variants have been observed. RTN4RL2 antibody is predicted to not cross-react with other Nogo receptor-like proteins.
Swissprot #:
Q86UN3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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