JAKMIP1 Antibody
| Code | Size | Price |
|---|
| PSI-7165-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7165-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
JAKMIP1 Antibody: JAMIP1, MARLIN1, Gababrbp, GABABRBP, JAMIP1, Janus kinase and microtubule-interacting protein 1, GABA-B receptor-binding protein, Marlin-1
Application Note:
JAKMIP1 antibody can be used for detection of JAKMIP1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
JAKMIP1 Antibody: JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.
Background References:
- Costa V, Conte I, Ziviello C, et al. Identification and expression analysis of novel Jakmip1 transcripts. Gene 2007; 402:1-8.
- Vidal RL, Fuentes P, Valenzuela JI, et al. RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Mol. Cell Neurosci. 2012; epub.
- Libri V, Schulte D, Van Stijn A et al. Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes. J. Immunol. 2008; 181:5847-56
- Bill BR, Geschwind DH. Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr. Opin. Genet. Dev. 2009; 19:271-8.
Buffer:
JAKMIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
Rabbit polyclonal JAKMIP1 antibody was raised against a 16 amino acid peptide near the center of human JAKMIP1.
The immunogen is located within amino acids 260 - 310 of JAKMIP1.
The immunogen is located within amino acids 260 - 310 of JAKMIP1.
NCBI Gene ID #:
152789
NCBI Official Name:
janus kinase and microtubule interacting protein 1
NCBI Official Symbol:
JAKMIP1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 69 kDa
Protein Accession #:
NP_653321
Protein GI Number:
21389505
Purification:
JAKMIP1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
Multiple isoforms of JAKMIP1 are known to exist. JAKMIP1 antibody is predicted to not cross-react with JAKMIP2.
Swissprot #:
Q96N16
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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