BCL3 Antibody
| Code | Size | Price |
|---|
| PSI-7183-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7183-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
BCL3 Antibody: BCL4, D19S37, BCL4, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL-3
Application Note:
BCL3 antibody can be used for detection of BCL3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ-B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ-B proteins. The expression of this gene can be induced by NF-κ-B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ-B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.
Background References:
- Ohno H, Takimoto G, and McKeithan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 1990; 60:991-7.
- Wulczyn FG, Naumann M, and Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature 1992; 358:597-9.
- Ibrahim HA, Amen F, Reid AG, et al. BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma. Eur. J. Haematol. 2011; 87:480-5.
- Ge B, Li O, Wilder P, et al. NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer. J. Immunol. 2003; 171:4210-8.
Buffer:
BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal BCL3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human BCL3.
The immunogen is located within amino acids 360 - 410 of BCL3.
The immunogen is located within amino acids 360 - 410 of BCL3.
NCBI Gene ID #:
602
NCBI Official Name:
B-cell CLL/lymphoma 3
NCBI Official Symbol:
BCL3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 50 kDa
Protein Accession #:
NP_005169
Protein GI Number:
164664508
Purification:
BCL3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P20749
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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