PTGDR2 Antibody
| Code | Size | Price |
|---|
| PSI-7191-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7191-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PTGDR2 Antibody: DP2, DL1R, CD294, CRTH2, GPR44, Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells
Application Note:
PTGDR2 antibody can be used for detection of PTGDR2 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PTGDR2 Antibody: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
Background References:
- Nagata K, Hirai K, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 1999; 459:195-9.
- Shichijo M, Sugimoto H, Nagao K, et al. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockage abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. J. Pharmacol. Exp. Ther. 2003; 307:518-25.
- Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J. Immunol. 2005; 2056-60.
Buffer:
PTGDR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2.
The immunogen is located within amino acids 320 - 370 of PTGDR2.
The immunogen is located within amino acids 320 - 370 of PTGDR2.
NCBI Gene ID #:
11251
NCBI Official Name:
prostaglandin D2 receptor 2
NCBI Official Symbol:
PTGDR2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 43 kDa
Protein Accession #:
NP_004769
Protein GI Number:
153791424
Purification:
PTGDR2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
Swissprot #:
Q9Y5Y4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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