CARM1 Antibody
| Code | Size | Price |
|---|
| PSI-7219-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7219-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CARM1 Antibody: PRMT4, PRMT4, Histone-arginine methyltransferase CARM1, Coactivator-associated arginine methyltransferase 1
Application Note:
CARM1 antibody can be used for detection of CARM1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CARM1 Antibody: Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation. CARM1 functions as a transcriptional co-activator for various nuclear receptors and NF-κB. It has also been shown to methylate histone H3 arginines, inhibiting the binding of corepressors and protecting chromatin from deacetylation, thereby facilitating transcription.
Background References:
- Frankel A, Yadav N, Lee J, et al. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J. Biol. Chem. 2002; 277:3537-43.
- Wolf SS. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Cell Mol. Life Sci. 2009; 66:2109-21.
- Lee DY, Teyssier C, Strahl BD, et al. Role of protein methylation in regulation of transcription. Endocr. Rev. 2005; 26:147-70.
- Covic M, Hassa PO, Saccani S, et al. Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB dependent gene expression. EMBO J. 2005; 24:85-96.
Buffer:
CARM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal CARM1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CARM1.
The immunogen is located within amino acids 470 - 520 of CARM1.
The immunogen is located within amino acids 470 - 520 of CARM1.
NCBI Gene ID #:
10498
NCBI Official Name:
coactivator-associated arginine methyltransferase 1
NCBI Official Symbol:
CARM1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 67 kDa
Protein Accession #:
NP_954592
Protein GI Number:
40288288
Purification:
CARM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q86X55
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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