IL-15RA Antibody
| Code | Size | Price |
|---|
| PSI-7233-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7233-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
IL-15RA Antibody: CD215, Interleukin-15 receptor subunit alpha, IL-15 receptor subunit alpha
Application Note:
IL-15RA antibody can be used for detection of IL-15RA by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
IL-15RA Antibody: Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.
Background References:
- Giri JG, Kumaki S, Ahdieh M, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995; 14:3654-63.
- Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.
- Lorenz HM, Hieronymus T, Grunke M, et al. Differential role for IL-2 and IL-15 in the inhibition of apoptosis in short-term activated human lymphocytes. Scand. J. Immunol. 1997; 45:660-9.
Buffer:
IL-15RA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal IL-15RA antibody was raised against a 16 amino acid peptide near the center of human IL-15RA.
The immunogen is located within amino acids 40 - 90 of IL-15RA.
The immunogen is located within amino acids 40 - 90 of IL-15RA.
NCBI Gene ID #:
3601
NCBI Official Name:
interleukin 15 receptor, alpha
NCBI Official Symbol:
IL15RA
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 26, 30, 38 kDa
Observed: 30 kDa
Observed: 30 kDa
Protein Accession #:
NP_001243694
Protein GI Number:
377520151
Purification:
IL-15RA Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
Multiple isoforms of IL-15RA are known to exist.
Swissprot #:
Q13261
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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