CD59 Antibody
| Code | Size | Price |
|---|
| PSI-7235-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7235-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CD59 Antibody: 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20, CD59 glycoprotein, 1F5 antigen
Application Note:
CD59 antibody can be used for detection of CD59 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
CD59 Antibody: The complement regulatory protein CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and ultimately cerebral infarction.
Background References:
- Venneker GT and Asghar SS. CD59: a molecule involved in antigen presentation as well as downregulation of membrane attack complex. Exp. Clin. Immunogenet. 1992; 9:33-47.
- Kimberly FC, Sivasankar B, and Paul Morgan B. Alternative roles for CD59. Mol. Immunol. 2007; 44:73-81.
- Ninomiya H and Sims PJ. The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the ?b? domain of C9. J. Biol. Chem. 1992; 267:13675-80.
- Deckert M, Ticchioni M, Mari B, et al. The glycosylphosphatidylinositol-anchored CD59 protein stimulates both T cell receptor zeta/ZAP-70-dependent and ?independent signaling pathways in T cells. Eur. J. Immunol. 1995; 25:1815-22
Buffer:
CD59 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (86%)
Immunogen:
Rabbit polyclonal CD59 antibody was raised against a 14 amino acid peptide near the amino terminus of human CD59.
The immunogen is located within the first 50 amino acids of CD59.
The immunogen is located within the first 50 amino acids of CD59.
NCBI Gene ID #:
966
NCBI Official Name:
CD59 molecule, complement regulatory protein
NCBI Official Symbol:
CD59
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
14 kDa
Protein Accession #:
NP_000602
Protein GI Number:
10835165
Purification:
CD59 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
Swissprot #:
P13987
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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