PIBF1 Antibody
| Code | Size | Price |
|---|
| PSI-7237-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7237-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PIBF1 Antibody: PIBF, CEP90, C13orf24, PIBF, Progesterone-induced-blocking factor 1
Application Note:
PIBF1 antibody can be used for detection of PIBF1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.
Background References:
- Laskarin G, Tokmadzic VS, Strbo N, et al. Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am. J. Reprod. Immunol. 2002; 48:201-9.
- Lachmann M, Gelbmann D, Kalman E, et al. PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. Int. J. Cancer. 2004; 112:51-60
- Polgar B, Kispal G, Lachmann M, et al. Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. J. Immunol. 2003; 171:5956-63.
- Raghupathy R, Al-Mutawa E, Al-Azemi M, et al. Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. J. Reprod. Immunol. 2009; 80:91-9.
Buffer:
PIBF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal PIBF1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PIBF1.
The immunogen is located within amino acids 610 - 660 of PIBF1.
The immunogen is located within amino acids 610 - 660 of PIBF1.
NCBI Gene ID #:
10464
NCBI Official Name:
progesterone immunomodulatory binding factor 1
NCBI Official Symbol:
PIBF1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
NP_006337
Protein GI Number:
5576958
Purification:
PIBF1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
Multiple isoforms of PIBF1 exists as a result of alternative splicing event.
Swissprot #:
Q8WXW3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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