TNFSF4 Antibody
| Code | Size | Price |
|---|
| PSI-7243-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7243-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TNFSF4 Antibody: GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40L
Application Note:
TNFSF4 antibody can be used for detection of TNFSF4 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
Background References:
- Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.
- OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98
Buffer:
TNFSF4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (91%)
Immunogen:
Rabbit polyclonal TNFSF4 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TNFSF4.
The immunogen is located within the last 50 amino acids of TNFSF4.
The immunogen is located within the last 50 amino acids of TNFSF4.
NCBI Gene ID #:
7292
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 4
NCBI Official Symbol:
TNFSF4
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
20 kDa
Protein Accession #:
NP_003317
Protein GI Number:
4507603
Purification:
TNFSF4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms.
Swissprot #:
P23510
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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