AGR2 Antibody

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ProSci
Product Code: PSI-7247
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-7247-0.02mg0.02mg£150.00
Quantity:
PSI-7247-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of AGR2 in Hela cell lysate with AGR2 antibody at (A) 1 and (B) 2 μg/mL
2 / 3
Immunohistochemistry of AGR2 in human small intestine tissue with AGR2 antibody at 5 μg/ml.
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Immunofluorescence of AGR2 in human small intestine tissue with AGR2 antibody at 20 μg/ml.
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Western blot analysis of AGR2 in Hela cell lysate with AGR2 antibody at (A) 1 and (B) 2 μg/mL
Immunohistochemistry of AGR2 in human small intestine tissue with AGR2 antibody at 5 μg/ml.
Immunofluorescence of AGR2 in human small intestine tissue with AGR2 antibody at 20 μg/ml.

Documents

Further Information

Additional Names:
AGR2 Antibody: AG2, GOB-4, HAG-2, XAG-2, PDIA17, HEL-S-116, AG2, UNQ515/PRO1030, Anterior gradient protein 2 homolog, HPC8, AG-2
Application Note:
AGR2 antibody can be used for detection of AGR2 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
AGR2 Antibody: AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
Background References:
  • Zhang JS, Gong A, Cheville JC, et al. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer 2005; 43:249-59.
  • Zheng W, Rosenstiel P, Huse K, et al. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. Genes Immun. 2006; 7:11-8.
  • Gray TA, MacLaine NJ, Michie CO, et al. Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models. J. Immunol. Methods 2012; 378:20-32.
  • Darb-Esfahani S, Fritzsche F, Kristiansen G, et al. Anterior gradient protein 2 (AGR2) is an independent prognostic factor in ovarian high-grade serous carcinoma. Virchows Arch. 2012; 461:109-16.
Buffer:
AGR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal AGR2 antibody was raised against a 17 amino acid peptide near the amino terminus of human AGR2.

The immunogen is located within the first 50 amino acids of AGR2.
NCBI Gene ID #:
10551
NCBI Official Name:
anterior gradient 2 homolog (Xenopus laevis)
NCBI Official Symbol:
AGR2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
Protein Accession #:
NP_006399
Protein GI Number:
5453541
Purification:
AGR2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
Two isoforms of AGR2 exists as a result of alternative splicing event.
Swissprot #:
O95994
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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