SDPR Antibody
| Code | Size | Price |
|---|
| PSI-7265-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7265-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SDPR Antibody: SDR, CAVIN2, PS-p68, cavin-2, Serum deprivation-response protein, Cavin-2
Application Note:
SDPR antibody can be used for detection of SDPR by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SDPR Antibody: The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.
Background References:
- Gustincich S, Vatta P, Goruppi S, et al. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics 1999; 57:120-9.
- Hansen CG, Bright NA, Howard G, et al. SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 2009; 11:807-14.
- Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.
Buffer:
SDPR Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal SDPR antibody was raised against an 18 amino acid peptide near the amino terminus of human SDPR.
The immunogen is located within the first 50 amino acids of SDPR.
The immunogen is located within the first 50 amino acids of SDPR.
NCBI Gene ID #:
8436
NCBI Official Name:
serum deprivation response
NCBI Official Symbol:
SDPR
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 22, 33, 43 kDa kDa
Observed: 30 kDa
Observed: 30 kDa
Protein Accession #:
NP_004648
Protein GI Number:
4759082
Purification:
SDPR Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
It is predicted to not cross-react with other members of the cavin family.
Swissprot #:
O95810
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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