GBP5 Antibody
| Code | Size | Price |
|---|
| PSI-7327-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7327-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
GBP5 Antibody: GBP-5, Guanylate-binding protein 5, GBP-TA antigen, GBP-5
Application Note:
GBP5 Antibody can be used for detection of GBP5 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
GBP5 Antibody: The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.
Background References:
- Vestal DJ. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.
- Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.
- Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.
- Shenoy AR, Wellington DA, Kumar P, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 2012; 336:481-5.
Buffer:
GBP5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GBP5 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human GBP5 .
The immunogen is located within the last 50 amino acids of GBP5.
The immunogen is located within the last 50 amino acids of GBP5.
NCBI Gene ID #:
115362
NCBI Official Name:
guanylate binding protein 5
NCBI Official Symbol:
GBP5
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 64 kDa
Observed: 66 kDa
Observed: 66 kDa
Protein Accession #:
NP_443174
Protein GI Number:
16418425
Purification:
GBP5 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
GBP5 antibody is predicted to not cross-react with other GBP family members.
Swissprot #:
Q96PP8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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