KAT5 Antibody
| Code | Size | Price |
|---|
| PSI-7339-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7339-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
KAT5 Antibody: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60
Application Note:
KAT5 antibody can be used for detection of KAT5 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
KAT5 Antibody: KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. KAT5 has been shown to play a role in DNA repair and apoptosis and is thought to play an important role in signal transduction and autophagy.
Background References:
- Kamine J, Elangovan B, Subramanian T, et al. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 1996; 216:357-66.
- Kimura A and Horikoshi M. Tip60 acetylates six lysines of a specific class of core histones in vitro. Genes Cells 1998; 3:789-800.
- Ikura T, Ogryzko VV, Grigoriev M, et al. Involvement of the TIP70 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102:463-73.
- Lin SY, Li TY, Liu Q, et al. GSK3-TIP60-ILK1 signaling pathway links growth factor deprivation to autophagy. Science 2012; 336:477-81.
Buffer:
KAT5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
KAT5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KAT5.
The immunogen is located within the last 50 amino acids of KAT5.
The immunogen is located within the last 50 amino acids of KAT5.
NCBI Gene ID #:
10524
NCBI Official Name:
K(lysine) acetyltransferase 5
NCBI Official Symbol:
KAT5
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 51, 54, 56, 60 kDa
Observed: 53 kDa
Observed: 53 kDa
Protein Accession #:
NP_874369
Protein GI Number:
36287069
Purification:
KAT5 Antibody is affinity chromatography purified via peptide column.
Research Area:
Autophagy
SPECIFICITY:
Multiple isoforms of KAT5 are known to exist.
Swissprot #:
Q92993
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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